ACTN3 Gene

The ACTN3 gene encodes the Alpha-actinin protein which is involved in the composition of skeletal muscle.

Alleles

People normally have two alleles per gene, one inherited from their mother and one inherited from their father.

Off (Eurasian)

This allele originates from an ancient Eurasian mutation that occurred thousands of years ago.

On (Global)

This allele has been widespread globally for tens of thousands of years.

Allele Pairs

It is the combination of a person's pair of gene alleles that influences traits.

 Influence Slower Sprinting
Allele Pair While Olympic sprinters tend to not have this allele pair, the collective influence of many environmental factors, such as training and diet, as well as other genes have a far greater impact on sprinting performance than ACTN3 alone.
 Influence Faster Sprinting
Allele Pair While Olympic sprinters tend to have these allele pairs, the collective influence of many environmental factors, such as training and diet, as well as other genes have a far greater impact on sprinting performance than ACTN3 alone.

Gene Details

The ACTN3 gene is located on chromosome 11 and encodes the protein named "Alpha-actinin-3 (alpha-actin-binding)", which influences the reported traits.

Additional References ACTN3
Wikipedia ACTN3
SNPedia ACTN3
UniProt Q08043
U.S. National Center for Biotechnology Information 89

Allele Definitions

[0]
On
C
G
Off
T
A
Show Minus Strand
+
-
Single Nucleotide Polymorphisms (SNPs)
[0] rs1815739 dbSNP SNPedia